Kinesin-like protein KIF25 (KIF25)

About Kinesin-like protein KIF25

Kinesin-like protein KIF25 (KIF25) is a protein from Homo sapiens identified by UniProt accession Q9UIL4, 384 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Kinesin-like protein KIF25
UniProt accession	Q9UIL4
Gene	KIF25
Organism	Homo sapiens
Length	384 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.50
bone quantitative ultrasound measurement · score 0.42
brain measurement · score 0.33
neurodegenerative disease · score 0.28
Parkinson disease · score 0.28
lysosomal storage disease · score 0.28
multiple sclerosis · score 0.28
Alzheimer disease · score 0.28
ovarian cancer · score 0.18
low grade glioma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UIL4-F1	alphafold	PREDICTED	71.60	—

Amino-acid sequence (384 residues)

MTWTSGQLQR EKQARPGSGA VLAFPDDKDL RVYGPAESQS AVFGDVCPLL TSLLDGYNVC VMAYGQTGSG KSYTMLGRHS DDGPVLPLDP QSDLGIIPRV AEELFRLILE NTSRSPKVEV SIVEVYNNDI FDLLAKDSIA AVSGVKREVV TAKDGRTEVA LLASEAVGSA SKLMELVHGG LQLRAKHPTL VHADSSRSHL IITVTLTTAS CSDSTADQAC SATLPREQTE AGRAGRSRRA SQGALAPQLV PGNPAGHAEQ VQARLQLVDS AGSECVGVSG VTGLALREMA CISRSLAALA GVLGALLEHR GHAPYRNSRL THLLQDCLGG DAKLLVILCI SPSQRHLAQT LQGLGFGIRA RQVQRGPARK KPPSSQTEGK RRPD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards