FK506-binding protein-like (FKBPL)

About FK506-binding protein-like

FK506-binding protein-like (FKBPL) is a protein from Homo sapiens identified by UniProt accession Q9UIM3, 349 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	FK506-binding protein-like
UniProt accession	Q9UIM3
Gene	FKBPL
Organism	Homo sapiens
Length	349 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
breast adenocarcinoma · score 0.25
head and neck squamous cell carcinoma · score 0.18
lung adenocarcinoma · score 0.18
esophageal cancer · score 0.18
glioblastoma multiforme · score 0.18
squamous cell lung carcinoma · score 0.18
hepatocellular carcinoma · score 0.12
atopic eczema · score 0.12
age-related macular degeneration · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UIM3-F1	alphafold	PREDICTED	77.10	—

Amino-acid sequence (349 residues)

METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE VSPDPASQIL EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP DGSFVKKIVI RGHGLDKPKL GSCCRVLALG FPFGSGPPEG WTELTMGVGP WREETWGELI EKCLESMCQG EEAELQLPGH SGPPVRLTLA SFTQGRDSWE LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL LTLPPPGPPE RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards