Butyrophilin-like protein 2 (BTNL2)

About Butyrophilin-like protein 2

Butyrophilin-like protein 2 (BTNL2) is a protein from Homo sapiens identified by UniProt accession Q9UIR0, 482 residues long. MolForge cross-references it against 0 known binders and 174 disease associations.

Target properties

Protein name	Butyrophilin-like protein 2
UniProt accession	Q9UIR0
Gene	BTNL2
Organism	Homo sapiens
Length	482 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (174)

Diseases linked to this target (Open Targets).

BMI-adjusted waist-hip ratio · score 0.34
blood protein measurement · score 0.32
Epstein Barr virus nuclear antigen 1 IgG measurement · score 0.31
hepatitis C induced liver cirrhosis · score 0.31
Vitiligo · score 0.31
sarcoidosis · score 0.30
lung adenocarcinoma · score 0.30
response to vaccine · score 0.29
Crohn's disease · score 0.28
nephrotic syndrome · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UIR0-F1	alphafold	PREDICTED	85.86	—

Amino-acid sequence (482 residues)

MVDFPGYNLS GAVASFLFIL LTMKQSEDFR VIGPAHPILA GVGEDALLTC QLLPKRTTMH VEVRWYRSEP STPVFVHRDG VEVTEMQMEE YRGWVEWIEN GIAKGNVALK IHNIQPSDNG QYWCHFQDGN YCGETSLLLK VAGLGSAPSI HMEGPGESGV QLVCTARGWF PEPQVYWEDI RGEKLLAVSE HRIQDKDGLF YAEATLVVRN ASAESVSCLV HNPVLTEEKG SVISLPEKLQ TELASLKVNG PSQPILVRVG EDIQLTCYLS PKANAQSMEV RWDRSHRYPA VHVYMDGDHV AGEQMAEYRG RTVLVSDAID EGRLTLQILS ARPSDDGQYR CLFEKDDVYQ EASLDLKVVS LGSSPLITVE GQEDGEMQPM CSSDGWFPQP HVPWRDMEGK TIPSSSQALT QGSHGLFHVQ TLLRVTNISA VDVTCSISIP FLGEEKIATF SLSESRMTFL WKTLLVWGLL LAVAVGLPRK RS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards