About CCR4-NOT transcription complex subunit 7
CCR4-NOT transcription complex subunit 7 (CNOT7) is a protein
from Homo sapiens identified by UniProt accession
Q9UIV1, 285 residues long.
MolForge cross-references it against 0 known binders and
172 disease associations.
Target properties
| Protein name | CCR4-NOT transcription complex subunit 7 |
|---|
| UniProt accession | Q9UIV1 |
|---|
| Gene | CNOT7 |
|---|
| Organism | Homo sapiens |
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| Length | 285 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (172)
Diseases linked to this target (Open Targets).
- squamous cell lung carcinoma · score 0.23
- gastric adenocarcinoma · score 0.23
- lung adenocarcinoma · score 0.23
- asthma · score 0.21
- azoospermia · score 0.10
- partial chromosome Y deletion · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- neoplasm · score 0.08
- spermatogenic failure 63 · score 0.08
- spermatogenic failure 25 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UIV1-F1 | alphafold | PREDICTED | 90.68 | — |
Amino-acid sequence (285 residues)
MPAATVDHSQ RICEVWACNL DEEMKKIRQV IRKYNYVAMD TEFPGVVARP IGEFRSNADY QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP GTSTWQFNFK FNLTEDMYAQ DSIELLTTSG IQFKKHEEEG IETQYFAELL MTSGVVLCEG VKWLSFHSGY DFGYLIKILT NSNLPEEELD FFEILRLFFP VIYDVKYLMK SCKNLKGGLQ EVAEQLELER IGPQHQAGSD SLLTGMAFFK MREMFFEDHI DDAKYCGHLY GLGSGSSYVQ NGTGNAYEEE ANKQS
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