About Ventral anterior homeobox 2
Ventral anterior homeobox 2 (VAX2) is a protein
from Homo sapiens identified by UniProt accession
Q9UIW0, 290 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | Ventral anterior homeobox 2 |
|---|
| UniProt accession | Q9UIW0 |
|---|
| Gene | VAX2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 290 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (51)
Diseases linked to this target (Open Targets).
- atopic eczema · score 0.23
- gut microbiome measurement · score 0.22
- serum metabolite measurement · score 0.19
- urate measurement · score 0.11
- creatinine measurement · score 0.10
- papillary thyroid carcinoma · score 0.08
- gonorrhea · score 0.07
- coloboma of macula · score 0.06
- microphthalmia, isolated, with coloboma 7 · score 0.05
- cystatin C measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UIW0-F1 | alphafold | PREDICTED | 68.93 | — |
Amino-acid sequence (290 residues)
MGDGGAERDR GPARRAESGG GGGRCGDRSG AGDLRADGGG HSPTEVAGTS ASSPAGSRES GADSDGQPGP GEADHCRRIL VRDAKGTIRE IVLPKGLDLD RPKRTRTSFT AEQLYRLEME FQRCQYVVGR ERTELARQLN LSETQVKVWF QNRRTKQKKD QSRDLEKRAS SSASEAFATS NILRLLEQGR LLSVPRAPSL LALTPSLPGL PASHRGTSLG DPRNSSPRLN PLSSASASPP LPPPLPAVCF SSAPLLDLPA GYELGSSAFE PYSWLERKVG SASSCKKANT
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