SH3 domain-binding glutamic acid-rich-like protein…

About SH3 domain-binding glutamic acid-rich-like protein 2

SH3 domain-binding glutamic acid-rich-like protein 2 (SH3BGRL2) is a protein from Homo sapiens identified by UniProt accession Q9UJC5, 107 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	SH3 domain-binding glutamic acid-rich-like protein 2
UniProt accession	Q9UJC5
Gene	SH3BGRL2
Organism	Homo sapiens
Length	107 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

body mass index · score 0.29
gut microbiome measurement · score 0.09
neoplasm · score 0.08
nonpapillary renal cell carcinoma · score 0.08
contact dermatitis · score 0.04
esophageal squamous cell carcinoma · score 0.04
Combined immunodeficiency · score 0.04
vitamin D measurement · score 0.03
oral squamous cell carcinoma · score 0.03
BMI-adjusted waist circumference · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UJC5-F1	alphafold	PREDICTED	89.44	—

Amino-acid sequence (107 residues)

MVIRVFIASS SGFVAIKKKQ QDVVRFLEAN KIEFEEVDIT MSEEQRQWMY KNVPPEKKPT QGNPLPPQIF NGDRYCGDYD SFFESKESNT VFSFLGLKPR LASKAEP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

SH3 domain-binding glutamic acid-rich-like protein 2 (SH3BGRL2)