ERBB receptor feedback inhibitor 1 (ERRFI1)

About ERBB receptor feedback inhibitor 1

ERBB receptor feedback inhibitor 1 (ERRFI1) is a protein from Homo sapiens identified by UniProt accession Q9UJM3, 462 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.

Target properties

Protein name	ERBB receptor feedback inhibitor 1
UniProt accession	Q9UJM3
Gene	ERRFI1
Organism	Homo sapiens
Length	462 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (158)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.39
hair color · score 0.37
ulcerative colitis · score 0.36
lean body mass · score 0.34
body height · score 0.34
inflammatory bowel disease · score 0.34
balding measurement · score 0.31
hair colour measurement · score 0.31
fat body mass · score 0.31
Varicose veins · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UJM3-F1	alphafold	PREDICTED	56.55	—

Amino-acid sequence (462 residues)

MSIAGVAAQE IRVPLKTGFL HNGRAMGNMR KTYWSSRSEF KNNFLNIDPI TMAYSLNSSA QERLIPLGHA SKSAPMNGHC FAENGPSQKS SLPPLLIPPS ENLGPHEEDQ VVCGFKKLTV NGVCASTPPL TPIKNSPSLF PCAPLCERGS RPLPPLPISE ALSLDDTDCE VEFLTSSDTD FLLEDSTLSD FKYDVPGRRS FRGCGQINYA YFDTPAVSAA DLSYVSDQNG GVPDPNPPPP QTHRRLRRSH SGPAGSFNKP AIRISNCCIH RASPNSDEDK PEVPPRVPIP PRPVKPDYRR WSAEVTSSTY SDEDRPPKVP PREPLSPSNS RTPSPKSLPS YLNGVMPPTQ SFAPDPKYVS SKALQRQNSE GSASKVPCIL PIIENGKKVS STHYYLLPER PPYLDKYEKF FREAEETNGG AQIQPLPADC GISSATEKPD SKTKMDLGGH VKRKHLSYVV SP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards