2-Hydroxyacid oxidase 1 (HAO1)

About 2-Hydroxyacid oxidase 1

2-Hydroxyacid oxidase 1 (HAO1) is a protein from Homo sapiens identified by UniProt accession Q9UJM8, 370 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	2-Hydroxyacid oxidase 1
UniProt accession	Q9UJM8
Gene	HAO1
Organism	Homo sapiens
Length	370 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (88)

Diseases linked to this target (Open Targets).

calcium oxalate urolithiasis · score 0.52
nephrolithiasis susceptibility caused by SLC26A1 · score 0.52
primary hyperoxaluria type 1 · score 0.48
primary hyperoxaluria · score 0.47
colorectal cancer · score 0.42
traffic air pollution measurement · score 0.33
protein measurement · score 0.33
body height · score 0.31
colorectal adenoma · score 0.27
ossification of the posterior longitudinal ligament of the spine · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UJM8-F1	alphafold	PREDICTED	94.54	—

Amino-acid sequence (370 residues)

MLPRLICIND YEQHAKSVLP KSIYDYYRSG ANDEETLADN IAAFSRWKLY PRMLRNVAET DLSTSVLGQR VSMPICVGAT AMQRMAHVDG ELATVRACQS LGTGMMLSSW ATSSIEEVAE AGPEALRWLQ LYIYKDREVT KKLVRQAEKM GYKAIFVTVD TPYLGNRLDD VRNRFKLPPQ LRMKNFETST LSFSPEENFG DDSGLAAYVA KAIDPSISWE DIKWLRRLTS LPIVAKGILR GDDAREAVKH GLNGILVSNH GARQLDGVPA TIDVLPEIVE AVEGKVEVFL DGGVRKGTDV LKALALGAKA VFVGRPIVWG LAFQGEKGVQ DVLEILKEEF RLAMALSGCQ NVKVIDKTLV RKNPLAVSKI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards