About Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) is a protein
from Homo sapiens identified by UniProt accession
Q9UJS0, 675 residues long.
MolForge cross-references it against 0 known binders and
221 disease associations.
Target properties
| Protein name | Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial |
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| UniProt accession | Q9UJS0 |
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| Gene | SLC25A13 |
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| Organism | Homo sapiens |
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| Length | 675 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (221)
Diseases linked to this target (Open Targets).
- neonatal intrahepatic cholestasis due to citrin deficiency · score 0.78
- citrullinemia type II · score 0.66
- citrin deficiency · score 0.65
- citrullinemia · score 0.52
- adult-onset citrullinemia type I · score 0.50
- citrullinemia type I · score 0.41
- heel bone mineral density · score 0.40
- diet measurement · score 0.39
- genetic disorder · score 0.34
- bone quantitative ultrasound measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UJS0-F1 | alphafold | PREDICTED | 82.32 | — |
Amino-acid sequence (675 residues)
MAAAKVALTK RADPAELRTI FLKYASIEKN GEFFMSPNDF VTRYLNIFGE SQPNPKTVEL LSGVVDQTKD GLISFQEFVA FESVLCAPDA LFMVAFQLFD KAGKGEVTFE DVKQVFGQTT IHQHIPFNWD SEFVQLHFGK ERKRHLTYAE FTQFLLEIQL EHAKQAFVQR DNARTGRVTA IDFRDIMVTI RPHVLTPFVE ECLVAAAGGT TSHQVSFSYF NGFNSLLNNM ELIRKIYSTL AGTRKDVEVT KEEFVLAAQK FGQVTPMEVD ILFQLADLYE PRGRMTLADI ERIAPLEEGT LPFNLAEAQR QKASGDSARP VLLQVAESAY RFGLGSVAGA VGATAVYPID LVKTRMQNQR STGSFVGELM YKNSFDCFKK VLRYEGFFGL YRGLLPQLLG VAPEKAIKLT VNDFVRDKFM HKDGSVPLAA EILAGGCAGG SQVIFTNPLE IVKIRLQVAG EITTGPRVSA LSVVRDLGFF GIYKGAKACF LRDIPFSAIY FPCYAHVKAS FANEDGQVSP GSLLLAGAIA GMPAASLVTP ADVIKTRLQV AARAGQTTYS GVIDCFRKIL REEGPKALWK GAGARVFRSS PQFGVTLLTY ELLQRWFYID FGGVKPMGSE PVPKSRINLP APNPDHVGGY KLAVATFAGI ENKFGLYLPL FKPSVSTSKA IGGGP
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