Growth/differentiation factor 2 (GDF2)

About Growth/differentiation factor 2

Growth/differentiation factor 2 (GDF2) is a protein from Homo sapiens identified by UniProt accession Q9UK05, 429 residues long. MolForge cross-references it against 0 known binders and 233 disease associations.

Target properties

Protein name	Growth/differentiation factor 2
UniProt accession	Q9UK05
Gene	GDF2
Organism	Homo sapiens
Length	429 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (233)

Diseases linked to this target (Open Targets).

hereditary hemorrhagic telangiectasia · score 0.71
heritable pulmonary arterial hypertension · score 0.56
pulmonary arterial hypertension · score 0.46
erythrocyte count · score 0.28
colorectal neoplasm · score 0.26
hemoglobin measurement · score 0.26
hematocrit · score 0.26
systolic blood pressure · score 0.23
red blood cell density measurement · score 0.20
Abnormality of the cardiovascular system · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UK05-F1	alphafold	PREDICTED	74.61	—

Amino-acid sequence (429 residues)

MCPGALWVAL PLLSLLAGSL QGKPLQSWGR GSAGGNAHSP LGVPGGGLPE HTFNLKMFLE NVKVDFLRSL NLSGVPSQDK TRVEPPQYMI DLYNRYTSDK STTPASNIVR SFSMEDAISI TATEDFPFQK HILLFNISIP RHEQITRAEL RLYVSCQNHV DPSHDLKGSV VIYDVLDGTD AWDSATETKT FLVSQDIQDE GWETLEVSSA VKRWVRSDST KSKNKLEVTV ESHRKGCDTL DISVPPGSRN LPFFVVFSND HSSGTKETRL ELREMISHEQ ESVLKKLSKD GSTEAGESSH EEDTDGHVAA GSTLARRKRS AGAGSHCQKT SLRVNFEDIG WDSWIIAPKE YEAYECKGGC FFPLADDVTP TKHAIVQTLV HLKFPTKVGK ACCVPTKLSP ISVLYKDDMG VPTLKYHYEG MSVAECGCR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards