About F-box only protein 2
F-box only protein 2 (FBXO2) is a protein
from Homo sapiens identified by UniProt accession
Q9UK22, 296 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | F-box only protein 2 |
|---|
| UniProt accession | Q9UK22 |
|---|
| Gene | FBXO2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 296 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (101)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- hip bone size · score 0.24
- hearing loss · score 0.21
- hip bone mineral density · score 0.19
- clear cell renal carcinoma · score 0.18
- periodontal disorder · score 0.16
- Mental deterioration · score 0.14
- blood protein measurement · score 0.09
- deafness · score 0.07
- non-alcoholic fatty liver disease · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UK22-F1 | alphafold | PREDICTED | 88.04 | — |
Amino-acid sequence (296 residues)
MDGDGDPESV GQPEEASPEE QPEEASAEEE RPEDQQEEEA AAAAAYLDEL PEPLLLRVLA ALPAAELVQA CRLVCLRWKE LVDGAPLWLL KCQQEGLVPE GGVEEERDHW QQFYFLSKRR RNLLRNPCGE EDLEGWCDVE HGGDGWRVEE LPGDSGVEFT HDESVKKYFA SSFEWCRKAQ VIDLQAEGYW EELLDTTQPA IVVKDWYSGR SDAGCLYELT VKLLSEHENV LAEFSSGQVA VPQDSDGGGW MEISHTFTDY GPGVRFVRFE HGGQDSVYWK GWFGARVTNS SVWVEP
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