About N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA) is a protein
from Homo sapiens identified by UniProt accession
Q9UK23, 515 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase |
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| UniProt accession | Q9UK23 |
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| Gene | NAGPA |
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| Organism | Homo sapiens |
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| Length | 515 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.46
- lysosomal storage disease · score 0.46
- Parkinson disease · score 0.46
- neurodegenerative disease · score 0.46
- multiple sclerosis · score 0.46
- blood protein measurement · score 0.40
- mucocutaneous lymph node syndrome · score 0.25
- vasculitis · score 0.25
- stuttering, familial persistent, 2 · score 0.14
- genetic disorder · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UK23-F1 | alphafold | PREDICTED | 82.19 | — |
Amino-acid sequence (515 residues)
MATSTGRWLL LRLALFGFLW EASGGLDSGA SRDDDLLLPY PRARARLPRD CTRVRAGNRE HESWPPPPAT PGAGGLAVRT FVSHFRDRAV AGHLTRAVEP LRTFSVLEPG GPGGCAARRR ATVEETARAA DCRVAQNGGF FRMNSGECLG NVVSDERRVS SSGGLQNAQF GIRRDGTLVT GYLSEEEVLD TENPFVQLLS GVVWLIRNGS IYINESQATE CDETQETGSF SKFVNVISAR TAIGHDRKGQ LVLFHADGQT EQRGINLWEM AEFLLKQDVV NAINLDGGGS ATFVLNGTLA SYPSDHCQDN MWRCPRQVST VVCVHEPRCQ PPDCHGHGTC VDGHCQCTGH FWRGPGCDEL DCGPSNCSQH GLCTETGCRC DAGWTGSNCS EECPLGWHGP GCQRPCKCEH HCPCDPKTGN CSVSRVKQCL QPPEATLRAG ELSFFTRTAW LALTLALAFL LLISTAANLS LLLSRAERNR RLHGDYAYHP LQEMNGEPLA AEKEQPGGAH NPFKD
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