Transmembrane protein 59-like (TMEM59L)

About Transmembrane protein 59-like

Transmembrane protein 59-like (TMEM59L) is a protein from Homo sapiens identified by UniProt accession Q9UK28, 342 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Transmembrane protein 59-like
UniProt accession	Q9UK28
Gene	TMEM59L
Organism	Homo sapiens
Length	342 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

dental caries · score 0.16
dentures · score 0.16
blood protein measurement · score 0.14
PR interval · score 0.08
cancer · score 0.07
esophageal disease · score 0.06
neoplasm · score 0.05
breast carcinoma · score 0.05
mean corpuscular hemoglobin concentration · score 0.05
non-small cell lung carcinoma · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UK28-F1	alphafold	PREDICTED	61.47	—

Amino-acid sequence (342 residues)

MAAVALMPPP LLLLLLLASP PAASAPSARD PFAPQLGDTQ NCQLRCRDRD LGPQPSQAGL EGASESPYDR AVLISACERG CRLFSICRFV ARSSKPNATQ TECEAACVEA YVKEAEQQAC SHGCWSQPAE PEPEQKRKVL EAPSGALSLL DLFSTLCNDL VNSAQGFVSS TWTYYLQTDN GKVVVFQTQP IVESLGFQGG RLQRVEVTWR GSHPEALEVH VDPVGPLDKV RKAKIRVKTS SKAKVESEEP QDNDFLSCMS RRSGLPRWIL ACCLFLSVLV MLWLSCSTLV TAPGQHLKFQ PLTLEQHKGF MMEPDWPLYP PPSHACEDSL PPYKLKLDLT KL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards