About Zinc finger protein 580
Zinc finger protein 580 (ZNF580) is a protein
from Homo sapiens identified by UniProt accession
Q9UK33, 172 residues long.
MolForge cross-references it against 0 known binders and
18 disease associations.
Target properties
| Protein name | Zinc finger protein 580 |
|---|
| UniProt accession | Q9UK33 |
|---|
| Gene | ZNF580 |
|---|
| Organism | Homo sapiens |
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| Length | 172 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (18)
Diseases linked to this target (Open Targets).
- Familial exudative vitreoretinopathy · score 0.06
- X-linked retinal dysplasia · score 0.06
- choroidal dystrophy, central areolar, 1 · score 0.05
- severe early-childhood-onset retinal dystrophy · score 0.05
- X-linked retinoschisis · score 0.04
- retinitis pigmentosa · score 0.04
- coloboma of optic nerve · score 0.03
- melanoma · score 0.03
- high density lipoprotein cholesterol measurement · score 0.03
- hepatocellular carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UK33-F1 | alphafold | PREDICTED | 64.56 | — |
Amino-acid sequence (172 residues)
MLLLPPRPPH PRSSSPEAMD PPPPKAPPFP KAEGPSSTPS SAAGPRPPRL GRHLLIDANG VPYTYTVQLE EEPRGPPQRE APPGEPGPRK GYSCPECARV FASPLRLQSH RVSHSDLKPF TCGACGKAFK RSSHLSRHRA THRARAGPPH TCPLCPRRFQ DAAELAQHVR LH
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