Inhibitor of growth protein 1 (ING1)

About Inhibitor of growth protein 1

Inhibitor of growth protein 1 (ING1) is a protein from Homo sapiens identified by UniProt accession Q9UK53, 422 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Inhibitor of growth protein 1
UniProt accession	Q9UK53
Gene	ING1
Organism	Homo sapiens
Length	422 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.55
endometrial cancer · score 0.33
neurodegenerative disease · score 0.26
C-reactive protein measurement · score 0.18
serum gamma-glutamyl transferase measurement · score 0.16
coronary artery disease · score 0.09
neoplasm · score 0.08
oral squamous cell carcinoma · score 0.08
aspartate aminotransferase measurement · score 0.07
hepatocellular carcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UK53-F1	alphafold	PREDICTED	57.55	—

Amino-acid sequence (422 residues)

MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG RVDLNVFGSL GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG GSRGAGRVSR WPPPHWLEAW RVSPLPLSPL SPATFGRGFI AVAVIPGLWA RGRGCSSDRL PRPAGPARRQ FQAASLLTRG WGRAWPWKQI LKELDECYER FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE LVENRTRQVD SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP NEPTYCLCNQ VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR GENEKTMDKA LEKSKKERAY NR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards