Protein Z-dependent protease inhibitor (SERPINA10)

About Protein Z-dependent protease inhibitor

Protein Z-dependent protease inhibitor (SERPINA10) is a protein from Homo sapiens identified by UniProt accession Q9UK55, 444 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Protein Z-dependent protease inhibitor
UniProt accession	Q9UK55
Gene	SERPINA10
Organism	Homo sapiens
Length	444 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.32
low density lipoprotein cholesterol measurement · score 0.17
total cholesterol measurement · score 0.08
platelet count · score 0.06
apolipoprotein B measurement · score 0.06
total iron binding capacity · score 0.05
colorectal cancer · score 0.04
esophageal adenocarcinoma · score 0.03
deep vein thrombosis · score 0.02
neoplasm · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UK55-F1	alphafold	PREDICTED	86.73	—

Amino-acid sequence (444 residues)

MKVVPSLLLS VLLAQVWLVP GLAPSPQSPE TPAPQNQTSR VVQAPKEEEE DEQEASEEKA SEEEKAWLMA SRQQLAKETS NFGFSLLRKI SMRHDGNMVF SPFGMSLAMT GLMLGATGPT ETQIKRGLHL QALKPTKPGL LPSLFKGLRE TLSRNLELGL TQGSFAFIHK DFDVKETFFN LSKRYFDTEC VPMNFRNASQ AKRLMNHYIN KETRGKIPKL FDEINPETKL ILVDYILFKG KWLTPFDPVF TEVDTFHLDK YKTIKVPMMY GAGKFASTFD KNFRCHVLKL PYQGNATMLV VLMEKMGDHL ALEDYLTTDL VETWLRNMKT RNMEVFFPKF KLDQKYEMHE LLRQMGIRRI FSPFADLSEL SATGRNLQVS RVLQRTVIEV DERGTEAVAG ILSEITAYSM PPVIKVDRPF HFMIYEETSG MLLFLGRVVN PTLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards