Cyclin-L1 (CCNL1)

About Cyclin-L1

Cyclin-L1 (CCNL1) is a protein from Homo sapiens identified by UniProt accession Q9UK58, 526 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.

Target properties

Protein name	Cyclin-L1
UniProt accession	Q9UK58
Gene	CCNL1
Organism	Homo sapiens
Length	526 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (104)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
body height · score 0.29
body mass index · score 0.29
electrocardiography · score 0.27
triglyceride measurement · score 0.23
testosterone measurement · score 0.23
PR interval · score 0.21
coronary artery disease · score 0.19
neurofibrillary tangles measurement · score 0.19
BMI-adjusted waist-hip ratio · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UK58-F1	alphafold	PREDICTED	68.41	—

Amino-acid sequence (526 residues)

MASGPHSTAT AAAAASSAAP SAGGSSSGTT TTTTTTTGGI LIGDRLYSEV SLTIDHSLIP EERLSPTPSM QDGLDLPSET DLRILGCELI QAAGILLRLP QVAMATGQVL FHRFFYSKSF VKHSFEIVAM ACINLASKIE EAPRRIRDVI NVFHHLRQLR GKRTPSPLIL DQNYINTKNQ VIKAERRVLK ELGFCVHVKH PHKIIVMYLQ VLECERNQTL VQTAWNYMND SLRTNVFVRF QPETIACACI YLAARALQIP LPTRPHWFLL FGTTEEEIQE ICIETLRLYT RKKPNYELLE KEVEKRKVAL QEAKLKAKGL NPDGTPALST LGGFSPASKP SSPREVKAEE KSPISINVKT VKKEPEDRQQ ASKSPYNGVR KDSKRSRNSR SASRSRSRTR SRSRSHTPRR HYNNRRSRSG TYSSRSRSRS RSHSESPRRH HNHGSPHLKA KHTRDDLKSS NRHGHKRKKS RSRSQSKSRD HSDAAKKHRH ERGHHRDRRE RSRSFERSHK SKHHGGSRSG HGRHRR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards