About Lariat debranching enzyme
Lariat debranching enzyme (DBR1) is a protein
from Homo sapiens identified by UniProt accession
Q9UK59, 544 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | Lariat debranching enzyme |
|---|
| UniProt accession | Q9UK59 |
|---|
| Gene | DBR1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 544 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- xerosis and growth failure with immune and pulmonary dysfunction syndrome · score 0.45
- mean corpuscular volume · score 0.29
- genetic disorder · score 0.19
- ichthyosis · score 0.18
- mean reticulocyte volume · score 0.10
- esophageal squamous cell carcinoma · score 0.07
- early-onset non-syndromic cataract · score 0.06
- isolated ectopia lentis · score 0.06
- Cataract-microcornea syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UK59-F1 | alphafold | PREDICTED | 78.26 | — |
Amino-acid sequence (544 residues)
MRVAVAGCCH GELDKIYETL ALAERRGPGP VDLLLCCGDF QAVRNEADLR CMAVPPKYRH MQTFYRYYSG EKKAPVLTLF IGGNHEASNH LQELPYGGWV APNIYYLGLA GVVKYRGVRI GGISGIFKSH DYRKGHFECP PYNSSTIRSI YHVRNIEVYK LKQLKQPIDI FLSHDWPRSI YHYGNKKQLL KTKSFFRQEV ENNTLGSPAA SELLEHLKPT YWFSAHLHVK FAALMQHQAK DKGQTARATK FLALDKCLPH RDFLQILEIE HDPSAPDYLE YDIEWLTILR ATDDLINVTG RLWNMPENNG LHARWDYSAT EEGMKEVLEK LNHDLKVPCN FSVTAACYDP SKPQTQMQLI HRINPQTTEF CAQLGIIDIN VRLQKSKEEH HVCGEYEEQD DVESNDSGED QSEYNTDTSA LSSINPDEIM LDEEEDEDSI VSAHSGMNTP SVEPSDQASE FSASFSDVRI LPGSMIVSSD DTVDSTIDRE GKPGGTVESG NGEDLTKVPL KRLSDEHEPE QRKKIKRRNQ AIYAAVDDDD DDAA
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