About Protein fem-1 homolog B
Protein fem-1 homolog B (FEM1B) is a protein
from Homo sapiens identified by UniProt accession
Q9UK73, 627 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Protein fem-1 homolog B |
|---|
| UniProt accession | Q9UK73 |
|---|
| Gene | FEM1B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 627 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (57)
Diseases linked to this target (Open Targets).
- hematocrit · score 0.32
- hemoglobin measurement · score 0.28
- mean corpuscular hemoglobin concentration · score 0.17
- platelet crit · score 0.14
- IGF-1 measurement · score 0.10
- uterine fibroid · score 0.10
- insulin like growth factor measurement · score 0.09
- platelet count · score 0.09
- cortical surface area measurement · score 0.09
- MODY · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UK73-F1 | alphafold | PREDICTED | 94.46 | — |
Amino-acid sequence (627 residues)
MEGLAGYVYK AASEGKVLTL AALLLNRSES DIRYLLGYVS QQGGQRSTPL IIAARNGHAK VVRLLLEHYR VQTQQTGTVR FDGYVIDGAT ALWCAAGAGH FEVVKLLVSH GANVNHTTVT NSTPLRAACF DGRLDIVKYL VENNANISIA NKYDNTCLMI AAYKGHTDVV RYLLEQRADP NAKAHCGATA LHFAAEAGHI DIVKELIKWR AAIVVNGHGM TPLKVAAESC KADVVELLLS HADCDRRSRI EALELLGASF ANDRENYDII KTYHYLYLAM LERFQDGDNI LEKEVLPPIH AYGNRTECRN PQELESIRQD RDALHMEGLI VRERILGADN IDVSHPIIYR GAVYADNMEF EQCIKLWLHA LHLRQKGNRN THKDLLRFAQ VFSQMIHLNE TVKAPDIECV LRCSVLEIEQ SMNRVKNISD ADVHNAMDNY ECNLYTFLYL VCISTKTQCS EEDQCKINKQ IYNLIHLDPR TREGFTLLHL AVNSNTPVDD FHTNDVCSFP NALVTKLLLD CGAEVNAVDN EGNSALHIIV QYNRPISDFL TLHSIIISLV EAGAHTDMTN KQNKTPLDKS TTGVSEILLK TQMKMSLKCL AARAVRANDI NYQDQIPRTL EEFVGFH
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