About Ubiquitin carboxyl-terminal hydrolase 21
Ubiquitin carboxyl-terminal hydrolase 21 (USP21) is a protein
from Homo sapiens identified by UniProt accession
Q9UK80, 565 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 21 |
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| UniProt accession | Q9UK80 |
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| Gene | USP21 |
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| Organism | Homo sapiens |
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| Length | 565 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (124)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- ovarian cancer · score 0.23
- breast adenocarcinoma · score 0.23
- lysosomal storage disease · score 0.18
- head and neck squamous cell carcinoma · score 0.12
- neoplasm · score 0.10
- cholangiocarcinoma · score 0.08
- hepatocellular carcinoma · score 0.08
- renal cell carcinoma · score 0.08
- urinary bladder carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UK80-F1 | alphafold | PREDICTED | 69.72 | — |
Amino-acid sequence (565 residues)
MPQASEHRLG RTREPPVNIQ PRVGSKLPFA PRARSKERRN PASGPNPMLR PLPPRPGLPD ERLKKLELGR GRTSGPRPRG PLRADHGVPL PGSPPPTVAL PLPSRTNLAR SKSVSSGDLR PMGIALGGHR GTGELGAALS RLALRPEPPT LRRSTSLRRL GGFPGPPTLF SIRTEPPASH GSFHMISARS SEPFYSDDKM AHHTLLLGSG HVGLRNLGNT CFLNAVLQCL SSTRPLRDFC LRRDFRQEVP GGGRAQELTE AFADVIGALW HPDSCEAVNP TRFRAVFQKY VPSFSGYSQQ DAQEFLKLLM ERLHLEINRR GRRAPPILAN GPVPSPPRRG GALLEEPELS DDDRANLMWK RYLEREDSKI VDLFVGQLKS CLKCQACGYR STTFEVFCDL SLPIPKKGFA GGKVSLRDCF NLFTKEEELE SENAPVCDRC RQKTRSTKKL TVQRFPRILV LHLNRFSASR GSIKKSSVGV DFPLQRLSLG DFASDKAGSP VYQLYALCNH SGSVHYGHYT ALCRCQTGWH VYNDSRVSPV SENQVASSEG YVLFYQLMQE PPRCL
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