Dickkopf-like protein 1 (DKKL1)

About Dickkopf-like protein 1

Dickkopf-like protein 1 (DKKL1) is a protein from Homo sapiens identified by UniProt accession Q9UK85, 242 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.

Target properties

Protein name	Dickkopf-like protein 1
UniProt accession	Q9UK85
Gene	DKKL1
Organism	Homo sapiens
Length	242 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (55)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.26
multiple sclerosis · score 0.11
systemic lupus erythematosus · score 0.10
mean platelet volume · score 0.08
Rare genetic female infertility · score 0.07
azoospermia · score 0.06
male infertility with teratozoospermia due to single gene mutation · score 0.05
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.05
isolated congenital hypogonadotropic hypogonadism · score 0.05
spermatogenic failures 50 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UK85-F1	alphafold	PREDICTED	54.86	—

Amino-acid sequence (242 residues)

MGEASPPAPA RRHLLVLLLL LSTLVIPSAA APIHDADAQE SSLGLTGLQS LLQGFSRLFL KGNLLRGIDS LFSAPMDFRG LPGNYHKEEN QEHQLGNNTL SSHLQIDKMT DNKTGEVLIS ENVVASIQPA EGSFEGDLKV PRMEEKEALV PIQKATDSFH TELHPRVAFW IIKLPRRRSH QDALEGGHWL SEKRHRLQAI RDGLRKGTHK DVLEEGTESS SHSRLSPRKT HLLYILRPSR QL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards