About F-box only protein 10
F-box only protein 10 (FBXO10) is a protein
from Homo sapiens identified by UniProt accession
Q9UK96, 956 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | F-box only protein 10 |
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| UniProt accession | Q9UK96 |
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| Gene | FBXO10 |
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| Organism | Homo sapiens |
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| Length | 956 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (54)
Diseases linked to this target (Open Targets).
- lipoprotein-associated phospholipase A(2) measurement · score 0.16
- metabolite measurement · score 0.11
- Griscelli syndrome type 3 · score 0.06
- Griscelli disease · score 0.05
- Griscelli disease type 3 · score 0.05
- piebald trait-neurologic defects syndrome · score 0.05
- uncombable hair syndrome · score 0.05
- oculocutaneous albinism type 3 · score 0.05
- Piebald trait - neurologic defects · score 0.04
- Griscelli disease type 1 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UK96-F1 | alphafold | PREDICTED | 75.81 | — |
Amino-acid sequence (956 residues)
MEAGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL GCTECRHPNW PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL FRRRRERRTL SVGPGREFDS LGSALAMASL YDRIVLFPGV YEEQGEIILK VPVEIVGQGK LGEVALLASI DQHCSTTRLC NLVFTPAWFS PIMYKTTSGH VQFDNCNFEN GHIQVHGPGT CQVKFCTFKN THIFLHNVPL CVLENCEFVG SENNSVTVEG HPSADKNWAY KYLLGLIKSS PTFLPTEDSD FLMSLDLESR DQAWSPKTCD IVIEGSQSPT SPASSSPKPG SKAGSQEAEV GSDGERVAQT PDSSDGGLSP SGEDEDEDQL MYRLSYQVQG PRPVLGGSFL GPPLPGASIQ LPSCLVLNSL QQELQKDKEA MALANSVQGC LIRKCLFRDG KGGVFVCSHG RAKMEGNIFR NLTYAVRCIH NSKIIMLRND IYRCRASGIF LRLEGGGLIA GNNIYHNAEA GVDIRKKSNP LILCNQIHHG LRSGIVVLGN GKGIIRNNQI FSNKEAGIYI LYHGNPVVSG NHIFKGRAAG IAVNENGKGL ITENVIRENQ WGGVDIRRGG IPVLRSNLIC FGYSDGVVVG DEGKGLIEGN TIYANKGCGV WMMSSSLPHV TSNHVSYNGL YGVAVFSQKD GSSELPRGHR AQENFSEDGD AILWETELEK EDDPLRRPIT IALVESNSIN HNGASGLYVQ SSEALHVITN VIHANGDRGI TVAQSSQPTR VANNSISCNR QSGVKVEAQC KVELRGNGIY DNRGHGIITK GDSTIVIEND IIGNRGSGLQ LLPRSDTKVI KNRIHSFRAY GIAVRGRAKA LVQENIIFQG KTSKTIFQQI SNNRECIMQN NKFLVFKKKS DTWRLVNPPA RPHLENSLRR PSAAHNGQKV TAMATRITAR VEGGYHSNRS VFCTIL
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