F-box only protein 9 (FBXO9)

About F-box only protein 9

F-box only protein 9 (FBXO9) is a protein from Homo sapiens identified by UniProt accession Q9UK97, 447 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	F-box only protein 9
UniProt accession	Q9UK97
Gene	FBXO9
Organism	Homo sapiens
Length	447 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

smoking status measurement · score 0.20
clear cell renal carcinoma · score 0.18
pancreatic adenocarcinoma · score 0.18
age at first sexual intercourse measurement · score 0.17
smoking initiation · score 0.15
acute myeloid leukemia · score 0.08
neoplasm · score 0.08
hepatocellular carcinoma · score 0.07
cancer · score 0.06
attention deficit hyperactivity disorder · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UK97-F1	alphafold	PREDICTED	77.42	—

Amino-acid sequence (447 residues)

MPDIIWVFPP QAEAEEDCHS DTVRADDDEE NESPAETDLQ AQLQMFRAQW MFELAPGVSS SNLENRPCRA ARGSLQKTSA DTKGKQEQAK EEKARELFLK AVEEEQNGAL YEAIKFYRRA MQLVPDIEFK ITYTRSPDGD GVGNSYIEDN DDDSKMADLL SYFQQQLTFQ ESVLKLCQPE LESSQIHISV LPMEVLMYIF RWVVSSDLDL RSLEQLSLVC RGFYICARDP EIWRLACLKV WGRSCIKLVP YTSWREMFLE RPRVRFDGVY ISKTTYIRQG EQSLDGFYRA WHQVEYYRYI RFFPDGHVMM LTTPEEPQSI VPRLRTRNTR TDAILLGHYR LSQDTDNQTK VFAVITKKKE EKPLDYKYRY FRRVPVQEAD QSFHVGLQLC SSGHQRFNKL IWIHHSCHIT YKSTGETAVS AFEIDKMYTP LFFARVRSYT AFSERPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards