F-box only protein 3 (FBXO3)

About F-box only protein 3

F-box only protein 3 (FBXO3) is a protein from Homo sapiens identified by UniProt accession Q9UK99, 471 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	F-box only protein 3
UniProt accession	Q9UK99
Gene	FBXO3
Organism	Homo sapiens
Length	471 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

chronotype measurement · score 0.37
diet measurement · score 0.25
calcium measurement · score 0.14
neoplasm · score 0.08
blood phosphate measurement · score 0.06
blood protein measurement · score 0.06
eosinophil count · score 0.02
sleep measurement · score 0.02
Rheumatoid arthritis · score 0.01
infection · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UK99-F1	alphafold	PREDICTED	88.69	—

Amino-acid sequence (471 residues)

MAAMETETAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD PLWRRHCKKY WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW DDLKKYLEPR CPRMVLSLKE GAREEDLDAV EAQIGCKLPD DYRCSYRIHN GQKLVVPGLL GSMALSNHYR SEDLLDVDTA AGGFQQRQGL KYCLPLTFCI HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI IGATFTDWFT SYVKNVVSGG FPIIRDQIFR YVHDPECVAT TGDITVSVST SFLPELSSVH PPHYFFTYRI RIEMSKDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG EFPIISPGRV YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK IFNVAIPRFH MACPTFRVSI ARLEMGPDEY EEMEEEEEEE EEEDEDDDSA DMDESDEDDE EERRRRVFDV PIRRRRCSRL F

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards