About F-box/LRR-repeat protein 4
F-box/LRR-repeat protein 4 (FBXL4) is a protein
from Homo sapiens identified by UniProt accession
Q9UKA2, 621 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | F-box/LRR-repeat protein 4 |
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| UniProt accession | Q9UKA2 |
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| Gene | FBXL4 |
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| Organism | Homo sapiens |
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| Length | 621 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- Mitochondrial DNA depletion syndrome, encephalomyopathic form with variable craniofacial anomalies · score 0.82
- mitochondrial DNA depletion syndrome 13 · score 0.80
- neurodegenerative disease · score 0.56
- Leigh syndrome · score 0.55
- genetic disorder · score 0.53
- mitochondrial DNA depletion syndrome · score 0.41
- Neurodevelopmental delay · score 0.34
- lysosomal storage disease · score 0.33
- mitochondrial encephalomyopathy · score 0.26
- Global developmental delay · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UKA2-F1 | alphafold | PREDICTED | 86.30 | — |
Amino-acid sequence (621 residues)
MSPVFPMLTV LTMFYYICLR RRARTATRGE MMNTHRAIES NSQTSPLNAE VVQYAKEVVD FSSHYGSENS MSYTMWNLAG VPNVFPSSGD FTQTAVFRTY GTWWDQCPSA SLPFKRTPPN FQSQDYVELT FEQQVYPTAV HVLETYHPGA VIRILACSAN PYSPNPPAEV RWEILWSERP TKVNASQARQ FKPCIKQINF PTNLIRLEVN SSLLEYYTEL DAVVLHGVKD KPVLSLKTSL IDMNDIEDDA YAEKDGCGMD SLNKKFSSAV LGEGPNNGYF DKLPYELIQL ILNHLTLPDL CRLAQTCKLL SQHCCDPLQY IHLNLQPYWA KLDDTSLEFL QSRCTLVQWL NLSWTGNRGF ISVAGFSRFL KVCGSELVRL ELSCSHFLNE TCLEVISEMC PNLQALNLSS CDKLPPQAFN HIAKLCSLKR LVLYRTKVEQ TALLSILNFC SELQHLSLGS CVMIEDYDVI ASMIGAKCKK LRTLDLWRCK NITENGIAEL ASGCPLLEEL DLGWCPTLQS STGCFTRLAH QLPNLQKLFL TANRSVCDTD IDELACNCTR LQQLDILGTR MVSPASLRKL LESCKDLSLL DVSFCSQIDN RAVLELNASF PKVFIKKSFT Q
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