Integrin beta-1-binding protein 2 (ITGB1BP2)

About Integrin beta-1-binding protein 2

Integrin beta-1-binding protein 2 (ITGB1BP2) is a protein from Homo sapiens identified by UniProt accession Q9UKP3, 347 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Integrin beta-1-binding protein 2
UniProt accession	Q9UKP3
Gene	ITGB1BP2
Organism	Homo sapiens
Length	347 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

breast carcinoma · score 0.04
pancreatic adenocarcinoma · score 0.04
Dilated cardiomyopathy · score 0.02
myocardial infarction · score 0.02
cardiomyopathy · score 0.01
hypertrophic cardiomyopathy · score 0.01
infection · score 0.01
infect · score 0.01
acute myocardial infarction · score 0.01
persistent truncus arteriosus · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UKP3-F1	alphafold	PREDICTED	79.07	—

Amino-acid sequence (347 residues)

MSLLCRNKGC GQHFDPNTNL PDSCCHHPGV PIFHDALKGW SCCRKRTVDF SEFLNIKGCT MGPHCAEKLP EAPQPEGPAT SSSLQEQKPL NVIPKSAETL RRERPKSELP LKLLPLNISQ ALEMALEQKE LDQEPGAGLD SLIRTGSSCQ NPGCDAVYQG PESDATPCTY HPGAPRFHEG MKSWSCCGIQ TLDFGAFLAQ PGCRVGRHDW GKQLPASCRH DWHQTDSLVV VTVYGQIPLP AFNWVKASQT ELHVHIVFDG NRVFQAQMKL WGVINVEQSS VFLMPSRVEI SLVKADPGSW AQLEHPDALA KKARAGVVLE MDEEESDDSD DDLSWTEEEE EEEAMGE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards