About Thyrotropin-releasing hormone-degrading ectoenzyme
Thyrotropin-releasing hormone-degrading ectoenzyme (TRHDE) is a protein
from Homo sapiens identified by UniProt accession
Q9UKU6, 1069 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | Thyrotropin-releasing hormone-degrading ectoenzyme |
|---|
| UniProt accession | Q9UKU6 |
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| Gene | TRHDE |
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| Organism | Homo sapiens |
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| Length | 1069 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (80)
Diseases linked to this target (Open Targets).
- wellbeing measurement · score 0.42
- depressive symptom measurement · score 0.30
- neuroticism measurement · score 0.30
- neurofibrillary tangles measurement · score 0.29
- risk-taking behaviour · score 0.28
- smoking status measurement · score 0.28
- substance abuse · score 0.28
- attention deficit hyperactivity disorder · score 0.28
- antisocial behaviour measurement · score 0.28
- adolescent idiopathic scoliosis · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UKU6-F1 | alphafold | PREDICTED | 84.58 | — |
Amino-acid sequence (1069 residues)
MALDGELGEQ EEEKKKKKKK KRKKKKEEEE EEEGAEKSSS PFAAAMGEDD AALRAGSRGL SDPWADSVGV RPRTTERHIA VHKRLVLAFA VSLVALLAVT MLAVLLSLRF DECGASATPG ADGGPSGFPE RGGNGSLPGS ARRNHHAGGD SWQPEAGGVA SPGTTSAQPP SEEEREPWEP WTQLRLSGHL KPLHYNLMLT AFMENFTFSG EVNVEIACRN ATRYVVLHAS RVAVEKVQLA EDRAFGAVPV AGFFLYPQTQ VLVVVLNRTL DAQRNYNLKI IYNALIENEL LGFFRSSYVL HGERRFLGVT QFSPTHARKA FPCFDEPIYK ATFKISIKHQ ATYLSLSNMP VETSVFEEDG WVTDHFSQTP LMSTYYLAWA ICNFTYRETT TKSGVVVRLY ARPDAIRRGS GDYALHITKR LIEFYEDYFK VPYSLPKLDL LAVPKHPYAA MENWGLSIFV EQRILLDPSV SSISYLLDVT MVIVHEICHQ WFGDLVTPVW WEDVWLKEGF AHYFEFVGTD YLYPGWNMEK QRFLTDVLHE VMLLDGLASS HPVSQEVLQA TDIDRVFDWI AYKKGAALIR MLANFMGHSV FQRGLQDYLT IHKYGNAARN DLWNTLSEAL KRNGKYVNIQ EVMDQWTLQM GYPVITILGN TTAENRIIIT QQHFIYDISA KTKALKLQNN SYLWQIPLTI VVGNRSHVSS EAIIWVSNKS EHHRITYLDK GSWLLGNINQ TGYFRVNYDL RNWRLLIDQL IRNHEVLSVS NRAGLIDDAF SLARAGYLPQ NIPLEIIRYL SEEKDFLPWH AASRALYPLD KLLDRMENYN IFNEYILKQV ATTYIKLGWP KNNFNGSLVQ ASYQHEELRR EVIMLACSFG NKHCHQQAST LISDWISSNR NRIPLNVRDI VYCTGVSLLD EDVWEFIWMK FHSTTAVSEK KILLEALTCS DDRNLLNRLL NLSLNSEVVL DQDAIDVIIH VARNPHGRDL AWKFFRDKWK ILNTRYGEAL FMNSKLISGV TEFLNTEGEL KELKNFMKNY DGVAAASFSR AVETVEANVR WKMLYQDELF QWLGKALRH
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