About BAG family molecular chaperone regulator 5
BAG family molecular chaperone regulator 5 (BAG5) is a protein
from Homo sapiens identified by UniProt accession
Q9UL15, 447 residues long.
MolForge cross-references it against 0 known binders and
219 disease associations.
Target properties
| Protein name | BAG family molecular chaperone regulator 5 |
|---|
| UniProt accession | Q9UL15 |
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| Gene | BAG5 |
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| Organism | Homo sapiens |
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| Length | 447 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (219)
Diseases linked to this target (Open Targets).
- cardiomyopathy, dilated, 2F · score 0.56
- familial isolated dilated cardiomyopathy · score 0.37
- cardiomyopathy · score 0.26
- genetic disorder · score 0.19
- unipolar depression · score 0.17
- intelligence · score 0.17
- cognitive function measurement · score 0.16
- self reported educational attainment · score 0.15
- autism spectrum disorder · score 0.15
- schizophrenia · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UL15-F1 | alphafold | PREDICTED | 90.46 | — |
Amino-acid sequence (447 residues)
MDMGNQHPSI SRLQEIQKEV KSVEQQVIGF SGLSDDKNYK KLERILTKQL FEIDSVDTEG KGDIQQARKR AAQETERLLK ELEQNANHPH RIEIQNIFEE AQSLVREKIV PFYNGGNCVT DEFEEGIQDI ILRLTHVKTG GKISLRKARY HTLTKICAVQ EIIEDCMKKQ PSLPLSEDAH PSVAKINFVM CEVNKARGVL IALLMGVNNN ETCRHLSCVL SGLIADLDAL DVCGRTEIRN YRREVVEDIN KLLKYLDLEE EADTTKAFDL RQNHSILKIE KVLKRMREIK NELLQAQNPS ELYLSSKTEL QGLIGQLDEV SLEKNPCIRE ARRRAVIEVQ TLITYIDLKE ALEKRKLFAC EEHPSHKAVW NVLGNLSEIQ GEVLSFDGNR TDKNYIRLEE LLTKQLLALD AVDPQGEEKC KAARKQAVRL AQNILSYLDL KSDEWEY
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