About Cilia- and flagella-associated protein 45
Cilia- and flagella-associated protein 45 (CFAP45) is a protein
from Homo sapiens identified by UniProt accession
Q9UL16, 551 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Cilia- and flagella-associated protein 45 |
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| UniProt accession | Q9UL16 |
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| Gene | CFAP45 |
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| Organism | Homo sapiens |
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| Length | 551 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (63)
Diseases linked to this target (Open Targets).
- heterotaxy, visceral, 9, autosomal, with male infertility · score 0.48
- situs inversus · score 0.37
- Male infertility due to sperm motility disorder · score 0.37
- non-small cell lung carcinoma · score 0.08
- mean platelet volume · score 0.08
- platelet component distribution width · score 0.07
- Heterotaxia · score 0.06
- monocyte count · score 0.05
- brain measurement · score 0.05
- visceral heterotaxy · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UL16-F1 | alphafold | PREDICTED | 76.25 | — |
Amino-acid sequence (551 residues)
MPLSTAGILS SSSAASNRSR NKARYRTKAV SSEVDESLFG DIKSPAQGQS DSPIVLLRDK HTLQKTLTAL GLDRKPETIQ LITRDMVREL IVPTEDPSGE SLIISPEEFE RIKWASHVLT REELEARDQA FKKEKEATMD AVMTRKKIMK QKEMVWNNNK KLSDLEEVAK ERAQNLLQRA NKLRMEQEEE LKDMSKIILN AKCHAIRDAQ ILEKQQIQKE LDTEEKRLDQ MMEVERQKSI QRQEELERKR REERIRGRRQ IVEQMEKNQE ERSLLAEQRE QEKEQMLEYM EQLQEEDLKD MERRQQQKLK MQAEIKRIND ENQKQKAELL AQEKLADQMV MEFTKKKMAR EAEFEAEQER IRREKEKEIA RLRAMQEKAQ DYQAEQDALR AKRNQEVADR EWRRKEKENA RKKMETEAEL RKSRLEQVAF KEHALAVQVQ RDRDEFERIL RAQREQIEKE RLEEEKKATG RLQHANELRR QVRENQQKEV QNRIATFEEG RRLKEEAQKR RERIDEIKRK KLEELRATGL PEKYCIEAER KANILPATSV N
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