About T-box transcription factor TBX21
T-box transcription factor TBX21 (TBX21) is a protein
from Homo sapiens identified by UniProt accession
Q9UL17, 535 residues long.
MolForge cross-references it against 0 known binders and
465 disease associations.
Target properties
| Protein name | T-box transcription factor TBX21 |
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| UniProt accession | Q9UL17 |
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| Gene | TBX21 |
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| Organism | Homo sapiens |
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| Length | 535 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (465)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- asthma, nasal polyps, and aspirin intolerance · score 0.44
- asthma · score 0.38
- mean corpuscular volume · score 0.33
- childhood onset asthma · score 0.32
- mean corpuscular hemoglobin concentration · score 0.31
- hypothyroidism · score 0.29
- total blood protein measurement · score 0.28
- autoimmune thyroid disease · score 0.27
- respiratory system disease · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UL17-F1 | alphafold | PREDICTED | 60.89 | — |
Amino-acid sequence (535 residues)
MGIVEPGCGD MLTGTEPMPG SDEGRAPGAD PQHRYFYPEP GAQDADERRG GGSLGSPYPG GALVPAPPSR FLGAYAYPPR PQAAGFPGAG ESFPPPADAE GYQPGEGYAA PDPRAGLYPG PREDYALPAG LEVSGKLRVA LNNHLLWSKF NQHQTEMIIT KQGRRMFPFL SFTVAGLEPT SHYRMFVDVV LVDQHHWRYQ SGKWVQCGKA EGSMPGNRLY VHPDSPNTGA HWMRQEVSFG KLKLTNNKGA SNNVTQMIVL QSLHKYQPRL HIVEVNDGEP EAACNASNTH IFTFQETQFI AVTAYQNAEI TQLKIDNNPF AKGFRENFES MYTSVDTSIP SPPGPNCQFL GGDHYSPLLP NQYPVPSRFY PDLPGQAKDV VPQAYWLGAP RDHSYEAEFR AVSMKPAFLP SAPGPTMSYY RGQEVLAPGA GWPVAPQYPP KMGPASWFRP MRTLPMEPGP GGSEGRGPED QGPPLVWTEI APIRPESSDS GLGEGDSKRR RVSPYPSSGD SSSPAGAPSP FDKEAEGQFY NYFPN
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