About Ras-related protein Rab-21
Ras-related protein Rab-21 (RAB21) is a protein
from Homo sapiens identified by UniProt accession
Q9UL25, 225 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Ras-related protein Rab-21 |
|---|
| UniProt accession | Q9UL25 |
|---|
| Gene | RAB21 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 225 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (38)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.47
- body mass index · score 0.32
- aspartate aminotransferase measurement · score 0.32
- low density lipoprotein cholesterol measurement · score 0.32
- small intestine cancer · score 0.25
- neutrophil count · score 0.22
- myeloid white cell count · score 0.11
- neoplasm · score 0.07
- nonpapillary renal cell carcinoma · score 0.05
- hepatocellular carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UL25-F1 | alphafold | PREDICTED | 82.00 | — |
Amino-acid sequence (225 residues)
MAAAGGGGGG AAAAGRAYSF KVVLLGEGCV GKTSLVLRYC ENKFNDKHIT TLQASFLTKK LNIGGKRVNL AIWDTAGQER FHALGPIYYR DSNGAILVYD ITDEDSFQKV KNWVKELRKM LGNEICLCIV GNKIDLEKER HVSIQEAESY AESVGAKHYH TSAKQNKGIE ELFLDLCKRM IETAQVDERA KGNGSSQPGT ARRGVQIIDD EPQAQTSGGG CCSSG
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