About Proteasome activator complex subunit 2
Proteasome activator complex subunit 2 (PSME2) is a protein
from Homo sapiens identified by UniProt accession
Q9UL46, 239 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Proteasome activator complex subunit 2 |
|---|
| UniProt accession | Q9UL46 |
|---|
| Gene | PSME2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 239 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- HIV infection · score 0.46
- lung adenocarcinoma · score 0.29
- gastric adenocarcinoma · score 0.28
- cancer · score 0.08
- neoplasm · score 0.08
- adamantinoma · score 0.07
- body height · score 0.06
- gonorrhea · score 0.06
- reticulum cell sarcoma · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UL46-F1 | alphafold | PREDICTED | 91.80 | — |
Amino-acid sequence (239 residues)
MAKPCGVRLS GEARKQVEVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED SLNVADLTSL RAPLDIPIPD PPPKDDEMET DKQEKKEVHK CGFLPGNEKV LSLLALVKPE VWTLKEKCIL VITWIQHLIP KIEDGNDFGV AIQEKVLERV NAVKTKVEAF QTTISKYFSE RGDAVAKASK ETHVMDYRAL VHERDEAAYG ELRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY
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