About Transcription factor-like 5 protein
Transcription factor-like 5 protein (TCFL5) is a protein
from Homo sapiens identified by UniProt accession
Q9UL49, 500 residues long.
MolForge cross-references it against 0 known binders and
198 disease associations.
Target properties
| Protein name | Transcription factor-like 5 protein |
|---|
| UniProt accession | Q9UL49 |
|---|
| Gene | TCFL5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 500 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (198)
Diseases linked to this target (Open Targets).
- multiple epiphyseal dysplasia, Beighton type · score 0.15
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- spermatogenic failures 50 · score 0.06
- spermatogenic failure 25 · score 0.06
- spinocerebellar ataxia type 32 · score 0.06
- congenital bilateral absence of vas deferens · score 0.06
- isochromosomy Yp · score 0.06
- spermatogenic failure, X-linked, 2 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UL49-F1 | alphafold | PREDICTED | 53.14 | — |
Amino-acid sequence (500 residues)
MSGPGPREPP PEAGAAGGEA AVEGAGGGDA ALGEPGLSFT TTDLSLVEMT EVEYTQLQHI LCSHMEAAAD GELETRLNSA LLAAAGPGAG AGGFAAGGQG GAAPVYPVLC PSALAADAPC LGHIDFQELR MMLLSEAGAA EKTSGGGDGA RARADGAAKE GAGAAAAAAG PDGAPEARAK PAVRVRLEDR FNSIPAEPPP APRGPEPPEP GGALNNLVTL IRHPSELMNV PLQQQNKCTA LVKNKTAATT TALQFTYPLF TTNACSTSGN SNLSQTQSSS NSCSVLEAAK HQDIGLPRAF SFCYQQEIES TKQTLGSRNK VLPEQVWIKV GEAALCKQAL KRNRSRMRQL DTNVERRALG EIQNVGEGAT ATQGAWQSSE SSQANLGEQA QSGPQGGRSQ RRERHNRMER DRRRRIRICC DELNLLVPFC NAETDKATTL QWTTAFLKYI QERHGDSLKK EFESVFCGKT GRRLKLTRPD SLVTCPAQGS LQSSPSMEIK
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