Transmembrane protease serine 11E (TMPRSS11E)

About Transmembrane protease serine 11E

Transmembrane protease serine 11E (TMPRSS11E) is a protein from Homo sapiens identified by UniProt accession Q9UL52, 423 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	Transmembrane protease serine 11E
UniProt accession	Q9UL52
Gene	TMPRSS11E
Organism	Homo sapiens
Length	423 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

total cholesterol measurement · score 0.52
sex hormone-binding globulin measurement · score 0.51
apolipoprotein A 1 measurement · score 0.48
serum alanine aminotransferase measurement · score 0.47
testosterone measurement · score 0.46
high density lipoprotein cholesterol measurement · score 0.46
IGF-1 measurement · score 0.46
low density lipoprotein cholesterol measurement · score 0.45
alkaline phosphatase measurement · score 0.45
urinary metabolite measurement · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UL52-F1	alphafold	PREDICTED	90.02	—

Amino-acid sequence (423 residues)

MMYRPDVVRA RKRVCWEPWV IGLVIFISLI VLAVCIGLTV HYVRYNQKKT YNYYSTLSFT TDKLYAEFGR EASNNFTEMS QRLESMVKNA FYKSPLREEF VKSQVIKFSQ QKHGVLAHML LICRFHSTED PETVDKIVQL VLHEKLQDAV GPPKVDPHSV KIKKINKTET DSYLNHCCGT RRSKTLGQSL RIVGGTEVEE GEWPWQASLQ WDGSHRCGAT LINATWLVSA AHCFTTYKNP ARWTASFGVT IKPSKMKRGL RRIIVHEKYK HPSHDYDISL AELSSPVPYT NAVHRVCLPD ASYEFQPGDV MFVTGFGALK NDGYSQNHLR QAQVTLIDAT TCNEPQAYND AITPRMLCAG SLEGKTDACQ GDSGGPLVSS DARDIWYLAG IVSWGDECAK PNKPGVYTRV TALRDWITSK TGI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards