About Long-chain-fatty-acid--CoA ligase 5
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) is a protein
from Homo sapiens identified by UniProt accession
Q9ULC5, 683 residues long.
MolForge cross-references it against 0 known binders and
189 disease associations.
Target properties
| Protein name | Long-chain-fatty-acid--CoA ligase 5 |
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| UniProt accession | Q9ULC5 |
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| Gene | ACSL5 |
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| Organism | Homo sapiens |
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| Length | 683 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (189)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.52
- platelet count · score 0.46
- mathematical ability · score 0.41
- triglyceride measurement · score 0.38
- total cholesterol measurement · score 0.31
- diacylglycerol 36:3 measurement · score 0.28
- basophil count · score 0.28
- cognitive function measurement · score 0.28
- amyotrophic lateral sclerosis · score 0.25
- basophil percentage of leukocytes · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9ULC5-F1 | alphafold | PREDICTED | 90.51 | — |
Amino-acid sequence (683 residues)
MLFIFNFLFS PLPTPALICI LTFGAAIFLW LITRPQPVLP LLDLNNQSVG IEGGARKGVS QKNNDLTSCC FSDAKTMYEV FQRGLAVSDN GPCLGYRKPN QPYRWLSYKQ VSDRAEYLGS CLLHKGYKSS PDQFVGIFAQ NRPEWIISEL ACYTYSMVAV PLYDTLGPEA IVHIVNKADI AMVICDTPQK ALVLIGNVEK GFTPSLKVII LMDPFDDDLK QRGEKSGIEI LSLYDAENLG KEHFRKPVPP SPEDLSVICF TSGTTGDPKG AMITHQNIVS NAAAFLKCVE HAYEPTPDDV AISYLPLAHM FERIVQAVVY SCGARVGFFQ GDIRLLADDM KTLKPTLFPA VPRLLNRIYD KVQNEAKTPL KKFLLKLAVS SKFKELQKGI IRHDSFWDKL IFAKIQDSLG GRVRVIVTGA APMSTSVMTF FRAAMGCQVY EAYGQTECTG GCTFTLPGDW TSGHVGVPLA CNYVKLEDVA DMNYFTVNNE GEVCIKGTNV FKGYLKDPEK TQEALDSDGW LHTGDIGRWL PNGTLKIIDR KKNIFKLAQG EYIAPEKIEN IYNRSQPVLQ IFVHGESLRS SLVGVVVPDT DVLPSFAAKL GVKGSFEELC QNQVVREAIL EDLQKIGKES GLKTFEQVKA IFLHPEPFSI ENGLLTPTLK AKRGELSKYF RTQIDSLYEH IQD
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