About Protein-arginine deiminase type-1
Protein-arginine deiminase type-1 (PADI1) is a protein
from Homo sapiens identified by UniProt accession
Q9ULC6, 663 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | Protein-arginine deiminase type-1 |
|---|
| UniProt accession | Q9ULC6 |
|---|
| Gene | PADI1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 663 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (54)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.41
- vitamin D deficiency · score 0.24
- breast adenocarcinoma · score 0.22
- neoplasm · score 0.08
- non-small cell lung carcinoma · score 0.05
- esophageal squamous cell carcinoma · score 0.05
- hypoparathyroidism, familial isolated, 2 · score 0.05
- cancer · score 0.04
- infection · score 0.04
- infect · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9ULC6-F1 | alphafold | PREDICTED | 94.56 | — |
Amino-acid sequence (663 residues)
MAPKRVVQLS LKMPTHAVCV VGVEAHVDIH SDVPKGANSF RVSGSSGVEV FMVYNRTRVK EPIGKARWPL DTDADMVVSV GTASKELKDF KVRVSYFGEQ EDQALGRSVL YLTGVDISLE VDTGRTGKVK RSQGDKKTWR WGPEGYGAIL LVNCDRDNHR SAEPDLTHSW LMSLADLQDM SPMLLSCNGP DKLFDSHKLV LNVPFSDSKR VRVFCARGGN SLSDYKQVLG PQCLSYEVER QPGEQEIKFY VEGLTFPDAD FLGLVSLSVS LVDPGTLPEV TLFTDTVGFR MAPWIMTPNT QPPEELYVCR VMDTHGSNEK FLEDMSYLTL KANCKLTICP QVENRNDRWI QDEMEFGYIE APHKSFPVVF DSPRNRGLKD FPYKRILGPD FGYVTREIPL PGPSSLDSFG NLDVSPPVTV GGTEYPLGRI LIGSSFPKSG GRQMARAVRN FLKAQQVQAP VELYSDWLSV GHVDEFLTFV PTSDQKGFRL LLASPSACLK LFQEKKEEGY GEAAQFDGLK HQAKRSINEM LADRHLQRDN LHAQKCIDWN RNVLKRELGL AESDIVDIPQ LFFLKNFYAE AFFPDMVNMV VLGKYLGIPK PYGPIINGRC CLEEKVQSLL EPLGLHCIFI DDYLSYHELQ GEIHCGTNVR RKPFPFKWWN MVP
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