About Paladin
Paladin (PALD1) is a protein
from Homo sapiens identified by UniProt accession
Q9ULE6, 856 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Paladin |
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| UniProt accession | Q9ULE6 |
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| Gene | PALD1 |
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| Organism | Homo sapiens |
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| Length | 856 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- Familial hemophagocytic lymphohistiocytosis · score 0.57
- Aplastic anemia · score 0.55
- autoinflammatory syndrome · score 0.52
- genetic disorder · score 0.52
- lymphoma · score 0.49
- neurodegenerative disease · score 0.46
- emphysema · score 0.07
- congenital lobar emphysema · score 0.04
- obesity due to SIM1 deficiency · score 0.03
- lymphocyte percentage of leukocytes · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9ULE6-F1 | alphafold | PREDICTED | 83.40 | — |
Amino-acid sequence (856 residues)
MGTTASTAQQ TVSAGTPFEG LQGSGTMDSR HSVSIHSFQS TSLHNSKAKS IIPNKVAPVV ITYNCKEEFQ IHDELLKAHY TLGRLSDNTP EHYLVQGRYF LVRDVTEKMD VLGTVGSCGA PNFRQVQGGL TVFGMGQPSL SGFRRVLQKL QKDGHRECVI FCVREEPVLF LRADEDFVSY TPRDKQNLHE NLQGLGPGVR VESLELAIRK EIHDFAQLSE NTYHVYHNTE DLWGEPHAVA IHGEDDLHVT EEVYKRPLFL QPTYRYHRLP LPEQGSPLEA QLDAFVSVLR ETPSLLQLRD AHGPPPALVF SCQMGVGRTN LGMVLGTLIL LHRSGTTSQP EAAPTQAKPL PMEQFQVIQS FLRMVPQGRR MVEEVDRAIT ACAELHDLKE VVLENQKKLE GIRPESPAQG SGSRHSVWQR ALWSLERYFY LILFNYYLHE QYPLAFALSF SRWLCAHPEL YRLPVTLSSA GPVAPRDLIA RGSLREDDLV SPDALSTVRE MDVANFRRVP RMPIYGTAQP SAKALGSILA YLTDAKRRLR KVVWVSLREE AVLECDGHTY SLRWPGPPVA PDQLETLEAQ LKAHLSEPPP GKEGPLTYRF QTCLTMQEVF SQHRRACPGL TYHRIPMPDF CAPREEDFDQ LLEALRAALS KDPGTGFVFS CLSGQGRTTT AMVVAVLAFW HIQGFPEVGE EELVSVPDAK FTKGEFQVVM KVVQLLPDGH RVKKEVDAAL DTVSETMTPM HYHLREIIIC TYRQAKAAKE AQEMRRLQLR SLQYLERYVC LILFNAYLHL EKADSWQRPF STWMQEVASK AGIYEILNEL GFPELESGED QPFSRLRYRW QEQSCSLEPS APEDLL
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