About Ataxin-7-like protein 1
Ataxin-7-like protein 1 (ATXN7L1) is a protein
from Homo sapiens identified by UniProt accession
Q9ULK2, 861 residues long.
MolForge cross-references it against 0 known binders and
157 disease associations.
Target properties
| Protein name | Ataxin-7-like protein 1 |
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| UniProt accession | Q9ULK2 |
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| Gene | ATXN7L1 |
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| Organism | Homo sapiens |
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| Length | 861 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (157)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.47
- hair color · score 0.41
- bone quantitative ultrasound measurement · score 0.40
- hair colour measurement · score 0.30
- self reported educational attainment · score 0.30
- skin pigmentation · score 0.29
- eosinophil count · score 0.26
- basophil count · score 0.22
- waist-hip ratio · score 0.22
- eosinophil percentage of leukocytes · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9ULK2-F1 | alphafold | PREDICTED | 50.63 | — |
Amino-acid sequence (861 residues)
MTSERSRIPC LSAAAAEGTG KKQQEGRAMA TLDRKVPSPE AFLGKPWSSW IDAAKLHCSD NVDLEEAGKE GGKSREVMRL NKEDMHLFGH YPAHDDFYLV VCSACNQVVK PQVFQSHCER RHGSMCRPSP SPVSPASNPR TSLVQVKTKA CLSGHHSASS TSKPFKTPKD NLLTSSSKQH TVFPAKGSRD KPCVPVPVVS LEKIPNLVKA DGANVKMNST TTTAVSASST SSSAVSTPPL IKPVLMSKSV PPSPEKILNG KGILPTTIDK KHQNGTKNSN KPYRRLSERE FDPNKHCGVL DPETKKPCTR SLTCKTHSLS HRRAVPGRKK QFDLLLAEHK AKSREKEVKD KEHLLTSTRE ILPSQSGPAQ DSLLGSSGSS GPEPKVASPA KSRPPNSVLP RPSSANSISS STSSNHSGHT PEPPLPPVGG DLASRLSSDE GEMDGADESE KLDCQFSTHH PRPLAFCSFG SRLMGRGYYV FDRRWDRFRF ALNSMVEKHL NSQMWKKIPP AADSPLPSPA AHITTPVPAS VLQPFSNPSA VYLPSAPISS RLTSSYIMTS AMLSNAAFVT SPDPSALMSH TTAFPHVAAT LSIMDSTFKA PSAVSPIPAV IPSPSHKPSK TKTSKSSKVK DLSTRSDESP SNKKRKPQSS TSSSSSSSSS SLQTSLSSPL SGPHKKNCVL NASSALNSYQ AAPPYNSLSV HNSNNGVSPL SAKLEPSGRT SLPGGPADIV RQVGAVGGSS DSCPLSVPSL ALHAGDLSLA SHNAVSSLPL SFDKSEGKKR KNSSSSSKAC KITKMPGMNS VHKKNPPSLL APVPDPVNST SSRQVGKNSS LALSQSSPSS ISSPGHSRQN TNRTGRIRTL P
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