About Pleckstrin homology domain-containing family G member 1
Pleckstrin homology domain-containing family G member 1 (PLEKHG1) is a protein
from Homo sapiens identified by UniProt accession
Q9ULL1, 1385 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Pleckstrin homology domain-containing family G member 1 |
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| UniProt accession | Q9ULL1 |
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| Gene | PLEKHG1 |
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| Organism | Homo sapiens |
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| Length | 1385 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- hypertension · score 0.51
- systolic blood pressure · score 0.51
- diastolic blood pressure · score 0.51
- white matter hyperintensity measurement · score 0.50
- Red cell distribution width · score 0.49
- alcohol consumption measurement · score 0.44
- alcohol drinking · score 0.44
- mean arterial pressure · score 0.44
- cortical thickness · score 0.41
- cortical surface area measurement · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9ULL1-F1 | alphafold | PREDICTED | 49.77 | — |
Amino-acid sequence (1385 residues)
MELSDSDRPV SFGSTSSSAS SRDSHGSFGS RMTLVSNSHM GLFNQDKEVG AIKLELIPAR PFSSSELQRD NPATGQQNAD EGSERPPRAQ WRVDSNGAPK TIADSATSPK LLYVDRVVQE ILETERTYVQ DLKSIVEDYL DCIRDQTKLP LGTEERSALF GNIQDIYHFN SELLQDLENC ENDPVAIAEC FVSKSEEFHI YTQYCTNYPR SVAVLTECMR NKILAKFFRE RQETLKHSLP LGSYLLKPVQ RILKYHLLLH EIENHLDKDT EGYDVVLDAI DTMQRVAWHI NDMKRKHEHA VRLQEIQSLL TNWKGPDLTS YGELVLEGTF RIQRAKNERT LFLFDKLLLI TKKRDDTFTY KAHILCGNLM LVEVIPKEPL SFSVFHYKNP KLQHTVQAKS QQDKRLWVLH LKRLILENHA AKIPAKAKQA ILEMDAIHHP GFCYSPEGGT KALFGSKEGS APYRLRRKSE PSSRSHKVLK TSETAQDIQK VSREEGSPQL SSARPSPAQR NSQPSSSTMI SVLRAGGALR NIWTDHQIRQ ALFPSRRSPQ ENEDDEDDYQ MFVPSFSSSD LNSTRLCEDS TSSRPCSWHM GQMESTETSS SGHRIVRRAS SAGESNTCPP EIGTSDRTRE LQNSPKTEGQ EEMTPFGSSI ELTIDDIDHV YDNISYEDLK LMVAKREEAE STPSKSARDS VRPKSTPELA FTKRQAGHSK GSLYAQTDGT LSGGEASSQS THELQAVEEN IYDTIGLPDP PSLGFKCSSL KRAKRSTFLG LEADFVCCDS LRPFVSQDSL QLSEDEAPYH QATPDHGYLS LLYDSPSGNL SMPHKPVSDK LSEEVDEIWN DLENYIKKNE DKARDRLLAA FPVSKDDVPD RLHAESTPEL SRDVGRSVST LSLPESQALL TPVKSRAGRA SRANCPFEED LISKEGSFMS LNRLSLASEM PLMDNPYDLA NSGLSQTDPE NPDLGMEATD KTKSRVFMMA RQYSQKIKKA NQLLKVKSLE LEQPPASQHQ KSMHKDLAAI LEEKKQGGPA IGARIAEYSQ LYDQIVFRES PLKIQKDGWA SPQESSLLRS VSPSQVHHGS GDWLLHSTYS NGELADFCLP PEQDLRSRYP TFEINTKSTP RQLSAACSVP SLQTSDPLPG SVQRCSVVVS QPNKENWCQD HLYNSLGRKG ISAKSQPYHR SQSSSSVLIN KSMDSINYPS DVGKQQLLSL HRSSRCESHQ DLLPDIADSH QQGTEKLSDL TLQDSQKVVV VNRNLPLNAQ IATQNYFSNF KETDGDEDDY VEIKSEEDES ELELSHNRRR KSDSKFVDAD FSDNVCSGNT LHSLNSPRTP KKPVNSKLGL SPYLTPYNDS DKLNDYLWRG PSPNQQNIVQ SLREKFQCLS SSSFA
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