About TBC1 domain family member 24
TBC1 domain family member 24 (TBC1D24) is a protein
from Homo sapiens identified by UniProt accession
Q9ULP9, 559 residues long.
MolForge cross-references it against 0 known binders and
161 disease associations.
Target properties
| Protein name | TBC1 domain family member 24 |
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| UniProt accession | Q9ULP9 |
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| Gene | TBC1D24 |
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| Organism | Homo sapiens |
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| Length | 559 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (161)
Diseases linked to this target (Open Targets).
- DOORS syndrome · score 0.81
- familial infantile myoclonic epilepsy · score 0.78
- rolandic epilepsy-paroxysmal exercise-induced dystonia-writer's cramp syndrome · score 0.76
- Rolandic epilepsy - paroxysmal exercise-induced dystonia - writer's cramp · score 0.73
- deafness · score 0.71
- autosomal dominant nonsyndromic hearing loss 65 · score 0.70
- autosomal recessive nonsyndromic hearing loss 86 · score 0.70
- malignant migrating partial seizures of infancy · score 0.64
- progressive myoclonic epilepsy with dystonia · score 0.64
- developmental and epileptic encephalopathy · score 0.57
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9ULP9-F1 | alphafold | PREDICTED | 84.12 | — |
Amino-acid sequence (559 residues)
MDSPGYNCFV DKDKMDAAIQ DLGPKELSCT ELQELKQLAR QGYWAQSHAL RGKVYQRLIR DIPCRTVTPD ASVYSDIVGK IVGKHSSSCL PLPEFVDNTQ VPSYCLNARG EGAVRKILLC LANQFPDISF CPALPAVVAL LLHYSIDEAE CFEKACRILA CNDPGRRLID QSFLAFESSC MTFGDLVNKY CQAAHKLMVA VSEDVLQVYA DWQRWLFGEL PLCYFARVFD VFLVEGYKVL YRVALAILKF FHKVRAGQPL ESDSVKQDIR TFVRDIAKTV SPEKLLEKAF AIRLFSRKEI QLLQMANEKA LKQKGITVKQ KSVSLSKRQF VHLAVHAENF RSEIVSVREM RDIWSWVPER FALCQPLLLF SSLQHGYSLA RFYFQCEGHE PTLLLIKTTQ KEVCGAYLST DWSERNKFGG KLGFFGTGEC FVFRLQPEVQ RYEWVVIKHP ELTKPPPLMA AEPTAPLSHS ASSDPADRLS PFLAARHFNL PSKTESMFMA GGSDCLIVGG GGGQALYIDG DLNRGRTSHC DTFNNQPLCS ENFLIAAVEA WGFQDPDTQ
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