About Pre-mRNA-splicing factor ISY1 homolog
Pre-mRNA-splicing factor ISY1 homolog (ISY1) is a protein
from Homo sapiens identified by UniProt accession
Q9ULR0, 285 residues long.
MolForge cross-references it against 0 known binders and
7 disease associations.
Target properties
| Protein name | Pre-mRNA-splicing factor ISY1 homolog |
|---|
| UniProt accession | Q9ULR0 |
|---|
| Gene | ISY1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 285 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (7)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.16
- volumetric bone mineral density · score 0.10
- muscular dystrophy · score 0.08
- BMI-adjusted hip circumference · score 0.05
- transient myeloproliferative syndrome · score 0.05
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 · score 0.04
- reticular dysgenesis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9ULR0-F1 | alphafold | PREDICTED | 80.21 | — |
Amino-acid sequence (285 residues)
MARNAEKAMT ALARFRQAQL EEGKVKERRP FLASECTELP KAEKWRRQII GEISKKVAQI QNAGLGEFRI RDLNDEINKL LREKGHWEVR IKELGGPDYG KVGPKMLDHE GKEVPGNRGY KYFGAAKDLP GVRELFEKEP LPPPRKTRAE LMKAIDFEYY GYLDEDDGVI VPLEQEYEKK LRAELVEKWK AEREARLARG EKEEEEEEEE EINIYAVTEE ESDEEGSQEK GGDDSQQKFI AHVPVPSQQE IEEALVRRKK MELLQKYASE TLQAQSEEAR RLLGY
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