About Protein phosphatase 1H
Protein phosphatase 1H (PPM1H) is a protein
from Homo sapiens identified by UniProt accession
Q9ULR3, 514 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Protein phosphatase 1H |
|---|
| UniProt accession | Q9ULR3 |
|---|
| Gene | PPM1H |
|---|
| Organism | Homo sapiens |
|---|
| Length | 514 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (69)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.47
- mean corpuscular volume · score 0.45
- heel bone mineral density · score 0.41
- mean corpuscular hemoglobin concentration · score 0.40
- mean corpuscular hemoglobin · score 0.39
- gut microbiome measurement · score 0.32
- neurodegenerative disease · score 0.26
- balding measurement · score 0.24
- body height · score 0.23
- spinal cord disease · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9ULR3-F1 | alphafold | PREDICTED | 83.94 | — |
Amino-acid sequence (514 residues)
MLTRVKSAVA NFMGGIMAGS SGSEHGGGSC GGSDLPLRFP YGRPEFLGLS QDEVECSADH IARPILILKE TRRLPWATGY AEVINAGKST HNEDQASCEV LTVKKKAGAV TSTPNRNSSK RRSSLPNGEG LQLKENSESE GVSCHYWSLF DGHAGSGAAV VASRLLQHHI TEQLQDIVDI LKNSAVLPPT CLGEEPENTP ANSRTLTRAA SLRGGVGAPG SPSTPPTRFF TEKKIPHECL VIGALESAFK EMDLQIERER SSYNISGGCT ALIVICLLGK LYVANAGDSR AIIIRNGEII PMSSEFTPET ERQRLQYLAF MQPHLLGNEF THLEFPRRVQ RKELGKKMLY RDFNMTGWAY KTIEDEDLKF PLIYGEGKKA RVMATIGVTR GLGDHDLKVH DSNIYIKPFL SSAPEVRIYD LSKYDHGSDD VLILATDGLW DVLSNEEVAE AITQFLPNCD PDDPHRYTLA AQDLVMRARG VLKDRGWRIS NDRLGSGDDI SVYVIPLIHG NKLS
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