About E3 ubiquitin-protein ligase ZNRF3
E3 ubiquitin-protein ligase ZNRF3 (ZNRF3) is a protein
from Homo sapiens identified by UniProt accession
Q9ULT6, 936 residues long.
MolForge cross-references it against 0 known binders and
252 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase ZNRF3 |
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| UniProt accession | Q9ULT6 |
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| Gene | ZNRF3 |
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| Organism | Homo sapiens |
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| Length | 936 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (252)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.46
- balding measurement · score 0.41
- hematocrit · score 0.40
- type 2 diabetes mellitus · score 0.38
- hypertension · score 0.35
- hair shape measurement · score 0.35
- red blood cell density measurement · score 0.33
- heel bone mineral density · score 0.33
- Follicular Cyst · score 0.32
- erythrocyte count · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9ULT6-F1 | alphafold | PREDICTED | 50.71 | — |
Amino-acid sequence (936 residues)
MRPRSGGRPG ATGRRRRRLR RRPRGLRCSR LPPPPPLPLL LGLLLAAAGP GAARAKETAF VEVVLFESSP SGDYTTYTTG LTGRFSRAGA TLSAEGEIVQ MHPLGLCNNN DEEDLYEYGW VGVVKLEQPE LDPKPCLTVL GKAKRAVQRG ATAVIFDVSE NPEAIDQLNQ GSEDPLKRPV VYVKGADAIK LMNIVNKQKV ARARIQHRPP RQPTEYFDMG IFLAFFVVVS LVCLILLVKI KLKQRRSQNS MNRLAVQALE KMETRKFNSK SKGRREGSCG ALDTLSSSST SDCAICLEKY IDGEELRVIP CTHRFHRKCV DPWLLQHHTC PHCRHNIIEQ KGNPSAVCVE TSNLSRGRQQ RVTLPVHYPG RVHRTNAIPA YPTRTSMDSH GNPVTLLTMD RHGEQSLYSP QTPAYIRSYP PLHLDHSLAA HRCGLEHRAY SPAHPFRRPK LSGRSFSKAA CFSQYETMYQ HYYFQGLSYP EQEGQSPPSL APRGPARAFP PSGSGSLLFP TVVHVAPPSH LESGSTSSFS CYHGHRSVCS GYLADCPGSD SSSSSSSGQC HCSSSDSVVD CTEVSNQGVY GSCSTFRSSL SSDYDPFIYR SRSPCRASEA GGSGSSGRGP ALCFEGSPPP EELPAVHSHG AGRGEPWPGP ASPSGDQVST CSLEMNYSSN SSLEHRGPNS STSEVGLEAS PGAAPDLRRT WKGGHELPSC ACCCEPQPSP AGPSAGAAGS STLFLGPHLY EGSGPAGGEP QSGSSQGLYG LHPDHLPRTD GVKYEGLPCC FYEEKQVARG GGGGSGCYTE DYSVSVQYTL TEEPPPGCYP GARDLSQRIP IIPEDVDCDL GLPSDCQGTH SLGSWGGTRG PDTPRPHRGL GATREEERAL CCQARALLRP GCPPEEAGAV RANFPSALQD TQESSTTATE AAGPRSHSAD SSSPGA
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