Apelin (APLN)

Homo sapiens — UniProt Q9ULZ1

Gene: APLNHomo sapiensSwissProt reviewed

About Apelin

Apelin (APLN) is a protein from Homo sapiens identified by UniProt accession Q9ULZ1, 77 residues long. MolForge cross-references it against 0 known binders and 465 disease associations.

Target properties

Protein nameApelin
UniProt accessionQ9ULZ1
GeneAPLN
OrganismHomo sapiens
Length77 residues
Molecular weight—
EC numbers—
Target classUNCLASSIFIED
Subcellular location—
Keywords—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tierMEDIUM
Druggability score—
Pocket score—
Max clinical phase—

Disease associations (465)

Diseases linked to this target (Open Targets).

  • neoplasm · score 0.12
  • type 2 diabetes mellitus · score 0.11
  • atrial fibrillation · score 0.10
  • Obesity · score 0.10
  • cancer · score 0.10
  • coronary artery disease · score 0.10
  • hepatocellular carcinoma · score 0.10
  • Stroke · score 0.10
  • chronic kidney disease · score 0.09
  • myocardial infarction · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

StructureSourceMethodMean pLDDTResolution (Å)
AF-Q9ULZ1-F1alphafoldPREDICTED67.13—

Amino-acid sequence (77 residues)

MNLRLCVQAL LLLWLSLTAV CGGSLMPLPD GNGLEDGNVR HLVQPRGSRN GPGPWQGGRR KFRRQRPRLS HKGPMPF

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Quick facts

UniProtQ9ULZ1
GeneAPLN
OrganismHomo sapiens
Length77
Binders0
Diseases465
View on UniProt