Signal-transducing adaptor protein 1 (STAP1)

About Signal-transducing adaptor protein 1

Signal-transducing adaptor protein 1 (STAP1) is a protein from Homo sapiens identified by UniProt accession Q9ULZ2, 295 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.

Target properties

Protein name	Signal-transducing adaptor protein 1
UniProt accession	Q9ULZ2
Gene	STAP1
Organism	Homo sapiens
Length	295 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (109)

Diseases linked to this target (Open Targets).

hypercholesterolemia, familial, 1 · score 0.27
body weight · score 0.25
gut microbiome measurement · score 0.15
self reported educational attainment · score 0.14
cognitive function measurement · score 0.13
intelligence · score 0.13
C-reactive protein measurement · score 0.11
smoking initiation · score 0.11
smoking status measurement · score 0.11
verbal-numerical reasoning measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9ULZ2-F1	alphafold	PREDICTED	78.52	—

Amino-acid sequence (295 residues)

MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLIKRSGYR EYEHYWTELR GTTLFFYTDK KSIIYVDKLD IVDLTCLTEQ NSTEKNCAKF TLVLPKEEVQ LKTENTESGE EWRGFILTVT ELSVPQNVSL LPGQVIKLHE VLEREKKRRI ETEQSTSVEK EKEPTEDYVD VLNPMPACFY TVSRKEATEM LQKNPSLGNM ILRPGSDSRN YSITIRQEID IPRIKHYKVM SVGQNYTIEL EKPVTLPNLF SVIDYFVKET RGNLRPFICS TDENTGQEPS MEGRSEKLKK NPHIA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards