Calcium load-activated calcium channel (TMCO1)

About Calcium load-activated calcium channel

Calcium load-activated calcium channel (TMCO1) is a protein from Homo sapiens identified by UniProt accession Q9UM00, 239 residues long. MolForge cross-references it against 0 known binders and 218 disease associations.

Target properties

Protein name	Calcium load-activated calcium channel
UniProt accession	Q9UM00
Gene	TMCO1
Organism	Homo sapiens
Length	239 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (218)

Diseases linked to this target (Open Targets).

Cerebro-facio-thoracic dysplasia · score 0.77
Cleft palate · score 0.50
genetic disorder · score 0.48
open-angle glaucoma · score 0.44
Abnormality of the skeletal system · score 0.37
craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome · score 0.37
cleft palate · score 0.37
Global developmental delay · score 0.34
renal agenesis · score 0.34
cryptorchidism · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UM00-F1	alphafold	PREDICTED	63.89	—

Amino-acid sequence (239 residues)

MPRKRKCDLR AVRVGLLLGG GGVYGSRFRF TFPGCRALSP WRVRVQRRRC EMSTMFADTL LIVFISVCTA LLAEGITWVL VYRTDKYKRL KAEVEKQSKK LEKKKETITE SAGRQQKKKI ERQEEKLKNN NRDLSMVRMK SMFAIGFCFT ALMGMFNSIF DGRVVAKLPF TPLSYIQGLS HRNLLGDDTT DCSFIFLYIL CTMSIRQNIQ KILGLAPSRA ATKQAGGFLG PPPPSGKFS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards