Y+L amino acid transporter 1 (SLC7A7)

About Y+L amino acid transporter 1

Y+L amino acid transporter 1 (SLC7A7) is a protein from Homo sapiens identified by UniProt accession Q9UM01, 511 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.

Target properties

Protein name	Y+L amino acid transporter 1
UniProt accession	Q9UM01
Gene	SLC7A7
Organism	Homo sapiens
Length	511 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (142)

Diseases linked to this target (Open Targets).

lysinuric protein intolerance · score 0.85
autoinflammatory syndrome · score 0.41
Sensorineural hearing impairment · score 0.37
HbA1c measurement · score 0.33
type 2 diabetes mellitus · score 0.27
heart failure · score 0.23
genetic disorder · score 0.19
glioblastoma multiforme · score 0.19
breast adenocarcinoma · score 0.18
obese body mass index status · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UM01-F1	alphafold	PREDICTED	83.80	—

Amino-acid sequence (511 residues)

MVDSTEYEVA SQPEVETSPL GDGASPGPEQ VKLKKEISLL NGVCLIVGNM IGSGIFVSPK GVLIYSASFG LSLVIWAVGG LFSVFGALCY AELGTTIKKS GASYAYILEA FGGFLAFIRL WTSLLIIEPT SQAIIAITFA NYMVQPLFPS CFAPYAASRL LAAACICLLT FINCAYVKWG TLVQDIFTYA KVLALIAVIV AGIVRLGQGA STHFENSFEG SSFAVGDIAL ALYSALFSYS GWDTLNYVTE EIKNPERNLP LSIGISMPIV TIIYILTNVA YYTVLDMRDI LASDAVAVTF ADQIFGIFNW IIPLSVALSC FGGLNASIVA ASRLFFVGSR EGHLPDAICM IHVERFTPVP SLLFNGIMAL IYLCVEDIFQ LINYYSFSYW FFVGLSIVGQ LYLRWKEPDR PRPLKLSVFF PIVFCLCTIF LVAVPLYSDT INSLIGIAIA LSGLPFYFLI IRVPEHKRPL YLRRIVGSAT RYLQVLCMSV AAEMDLEDGG EMPKQRDPKS N

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards