About Protein-arginine deiminase type-4
Protein-arginine deiminase type-4 (PADI4) is a protein
from Homo sapiens identified by UniProt accession
Q9UM07, 663 residues long.
MolForge cross-references it against 0 known binders and
447 disease associations.
Target properties
| Protein name | Protein-arginine deiminase type-4 |
|---|
| UniProt accession | Q9UM07 |
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| Gene | PADI4 |
|---|
| Organism | Homo sapiens |
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| Length | 663 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (447)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.63
- interstitial lung disease · score 0.49
- Abnormal pulmonary interstitial morphology · score 0.47
- basophil count · score 0.39
- basophil percentage of leukocytes · score 0.37
- neutrophil count · score 0.36
- neurodegenerative disease · score 0.32
- autoimmune disease · score 0.27
- breast adenocarcinoma · score 0.22
- hair shape measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UM07-F1 | alphafold | PREDICTED | 94.30 | — |
Amino-acid sequence (663 residues)
MAQGTLIRVT PEQPTHAVCV LGTLTQLDIC SSAPEDCTSF SINASPGVVV DIAHGPPAKK KSTGSSTWPL DPGVEVTLTM KVASGSTGDQ KVQISYYGPK TPPVKALLYL TGVEISLCAD ITRTGKVKPT RAVKDQRTWT WGPCGQGAIL LVNCDRDNLE SSAMDCEDDE VLDSEDLQDM SLMTLSTKTP KDFFTNHTLV LHVARSEMDK VRVFQATRGK LSSKCSVVLG PKWPSHYLMV PGGKHNMDFY VEALAFPDTD FPGLITLTIS LLDTSNLELP EAVVFQDSVV FRVAPWIMTP NTQPPQEVYA CSIFENEDFL KSVTTLAMKA KCKLTICPEE ENMDDQWMQD EMEIGYIQAP HKTLPVVFDS PRNRGLKEFP IKRVMGPDFG YVTRGPQTGG ISGLDSFGNL EVSPPVTVRG KEYPLGRILF GDSCYPSNDS RQMHQALQDF LSAQQVQAPV KLYSDWLSVG HVDEFLSFVP APDRKGFRLL LASPRSCYKL FQEQQNEGHG EALLFEGIKK KKQQKIKNIL SNKTLREHNS FVERCIDWNR ELLKRELGLA ESDIIDIPQL FKLKEFSKAE AFFPNMVNML VLGKHLGIPK PFGPVINGRC CLEEKVCSLL EPLGLQCTFI NDFFTYHIRH GEVHCGTNVR RKPFSFKWWN MVP
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