Fizzy-related protein homolog (FZR1)

About Fizzy-related protein homolog

Fizzy-related protein homolog (FZR1) is a protein from Homo sapiens identified by UniProt accession Q9UM11, 496 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	Fizzy-related protein homolog
UniProt accession	Q9UM11
Gene	FZR1
Organism	Homo sapiens
Length	496 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
undetermined early-onset epileptic encephalopathy · score 0.37
genetic disorder · score 0.34
Global developmental delay · score 0.29
lysosomal storage disease · score 0.28
Red cell distribution width · score 0.23
low grade glioma · score 0.23
clear cell renal carcinoma · score 0.18
endometrial cancer · score 0.14
Seizure · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UM11-F1	alphafold	PREDICTED	82.36	—

Amino-acid sequence (496 residues)

MDQDYERRLL RQIVIQNENT MPRVTEMRRT LTPASSPVSS PSKHGDRFIP SRAGANWSVN FHRINENEKS PSQNRKAKDA TSDNGKDGLA YSALLKNELL GAGIEKVQDP QTEDRRLQPS TPEKKGLFTY SLSTKRSSPD DGNDVSPYSL SPVSNKSQKL LRSPRKPTRK ISKIPFKVLD APELQDDFYL NLVDWSSLNV LSVGLGTCVY LWSACTSQVT RLCDLSVEGD SVTSVGWSER GNLVAVGTHK GFVQIWDAAA GKKLSMLEGH TARVGALAWN AEQLSSGSRD RMILQRDIRT PPLQSERRLQ GHRQEVCGLK WSTDHQLLAS GGNDNKLLVW NHSSLSPVQQ YTEHLAAVKA IAWSPHQHGL LASGGGTADR CIRFWNTLTG QPLQCIDTGS QVCNLAWSKH ANELVSTHGY SQNQILVWKY PSLTQVAKLT GHSYRVLYLA MSPDGEAIVT GAGDETLRFW NVFSKTRSTK VKWESVSVLN LFTRIR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards