HERV-H LTR-associating protein 2 (HHLA2)

About HERV-H LTR-associating protein 2

HERV-H LTR-associating protein 2 (HHLA2) is a protein from Homo sapiens identified by UniProt accession Q9UM44, 414 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.

Target properties

Protein name	HERV-H LTR-associating protein 2
UniProt accession	Q9UM44
Gene	HHLA2
Organism	Homo sapiens
Length	414 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (134)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.45
body mass index · score 0.42
cognitive function measurement · score 0.39
self reported educational attainment · score 0.39
age at first sexual intercourse measurement · score 0.39
body weight · score 0.38
smoking status measurement · score 0.34
antisocial behaviour measurement · score 0.32
attention deficit hyperactivity disorder · score 0.32
substance abuse · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UM44-F1	alphafold	PREDICTED	80.94	—

Amino-acid sequence (414 residues)

MKAQTALSFF LILITSLSGS QGIFPLAFFI YVPMNEQIVI GRLDEDIILP SSFERGSEVV IHWKYQDSYK VHSYYKGSDH LESQDPRYAN RTSLFYNEIQ NGNASLFFRR VSLLDEGIYT CYVGTAIQVI TNKVVLKVGV FLTPVMKYEK RNTNSFLICS VLSVYPRPII TWKMDNTPIS ENNMEETGSL DSFSINSPLN ITGSNSSYEC TIENSLLKQT WTGRWTMKDG LHKMQSEHVS LSCQPVNDYF SPNQDFKVTW SRMKSGTFSV LAYYLSSSQN TIINESRFSW NKELINQSDF SMNLMDLNLS DSGEYLCNIS SDEYTLLTIH TVHVEPSQET ASHNKGLWIL VPSAILAAFL LIWSVKCCRA QLEARRSRHP ADGAQQERCC VPPGERCPSA PDNGEENVPL SGKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards